Hydroxocobalamin 1mg/ml Injection
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Hydroxocobalamin 1mg/ml Injection is an injectable treatment used for vitamin b12 deficiency where clinically appropriate. It contains Hydroxocobalamin 1mg/ml.
Hydroxocobalamin is the standard injectable vitamin B12 replacement used in the UK. With neurological involvement, current product information uses 1 mg intramuscularly on alternate days while improvement continues, followed by maintenance commonly every 2 months. Without neurological involvement, licensed loading and maintenance schedules differ and are selected according to the clinical cause.
Suitability depends on your symptoms, medical history, current medicines, allergies, previous treatment and pregnancy or breastfeeding considerations where relevant.
How to use
Use Hydroxocobalamin 1mg/ml Injection exactly as directed by your pharmacist, prescriber or the patient information leaflet supplied with the product.
The treatment schedule for vitamin b12 deficiency is: Loading and maintenance regimen depends on cause. Do not change the dose, frequency or duration unless advised by a clinician.
Hydroxocobalamin is given by intramuscular injection. Loading frequency and long-term maintenance intervals depend on the cause of deficiency and whether neurological involvement is present.
NICE recommends lifelong intramuscular replacement for confirmed or suspected autoimmune gastritis, total gastrectomy and complete terminal ileal resection. Diagnosis should normally be established before treatment, but replacement should not be delayed where significant neurological deficiency is suspected.
If symptoms of vitamin b12 deficiency worsen, do not respond as expected or you develop a serious reaction, stop and seek appropriate clinical advice.
Main Ingredients
Hydroxocobalamin 1mg/ml Injection contains Hydroxocobalamin 1mg/ml as the main active ingredient or treatment component.
The exact formulation, excipients, device components or inactive ingredients can vary by manufacturer and pack supplied.
Always check the patient information leaflet or product instructions supplied with your specific pack, particularly if you have known allergies or intolerances.
Side Effects & Cautions
Injection-site reactions, headache, dizziness, nausea or rash can occur. Serious allergy is rare; potassium monitoring may be needed during intensive treatment of severe megaloblastic anaemia.
NICE recommends lifelong intramuscular replacement for confirmed or suspected autoimmune gastritis, total gastrectomy and complete terminal ileal resection. Diagnosis should normally be established before treatment, but replacement should not be delayed where significant neurological deficiency is suspected.
New or progressive neurological symptoms, marked gait disturbance, severe weakness or suspected subacute combined degeneration requires prompt medical assessment. Treatment should not be delayed solely while awaiting tests when significant neurological B12 deficiency is suspected.
Stop treatment and seek urgent medical help for difficulty breathing, swelling of the face, lips or tongue, collapse or another severe allergic reaction.
Suitability is confirmed through clinical assessment. Prescription medicine is supplied only where clinically appropriate.
Read the official patient information leaflet before using any medicine. The leaflet provides important information on use, cautions, side effects and storage.
Open leaflet on eMC